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Short answer: tirzepatide is a dual GLP-1/GIP receptor agonist that is already approved as a prescription medicine, while retatrutide adds a third receptor — glucagon — and remains investigational, approved nowhere

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✅ Semaglutide May Be Ideal If You: Have a BMI ≥30 or ≥27 with weight-related conditions Want long-term weight reduction with metabolic support Prefer a once-a-week solution Have diabetes or prediabetes ✅ Phentermine May Be Ideal If You: Need a short-term weight loss boost Want a low-cost daily option Don’t have cardiac or stimulant-related risk factors Are not a candidate for injectables Side Effects & Safety Semaglutide: Common side effects include nausea, constipation, and fatigue